During Sea of Simulation, shoot the right orbit to light Flynn's Arcade scoop. It will award you the next needed shot.
During Quorra multiball, hit the center bank of standup targets three times to add a ball. This can be done twice per multiball.
If you only need one more shot to light light cycle multiball you can plunge hard to get the light cycle shot behind the pop bumpers.
Any (combo of) shot(s) that ends with the upper ramp to left flipper enables an 'end of line' jackpot at the scoop. Big points to be had.